Cisplatin is a relatively simple Platinum compound discovered in 1845 and is especially interesting in that it exhibits synergism with a large number of currently-used chemotherapeutic agents.

Description & Properties :

Ref	MERCK INDEX 13th EDITION Originally known as Peyrone's salt of Peyrone's chloride.Deep yellow solid, Sol in water 0.253 g/100g at 25C; slowly changes to tran-form ijn aq soln. Insol in most common solvents. Sol in DMF. LD50 in guinea pigs : 9.7 mg/kg i.p. (Fleishman).
Note	This substance is reasonably anticipated to be a human carcinogen : Ninth Report on Carcinogens (PB2000 - 107509, 2000) p III - 93.
Usage	Used for the treatment of testicular, ovarian, small cell lung, bladder, cervical and head and neck carcinomas.
Specification	USP27, IP1996
Package	10, 50, 100, 200, 500 gms., packed in polythene pouch placed in stainless steel cans.

Result of continuous searches for a better, more active, more effective but less toxic Platinum complex as potential chemotherapy drugs terminated in the discovery of the second generation anticancer Platinum drugs, Carboplatin. Cisplatin and its successor drug, Carboplatin, are widely used in the treatment of other cancers. But since these drugs are often given to patients with advanced cancer, even a relatively limited success rate represents a genuine achievement.

Description & Properties :

Ref	MERCK INDEX 13th EDITION White crystals, Sol in water, LD50 in mice 150 i.p; 140 i.v.
Usage	Used for the treatment of spermary, ovarian, vesica, lung and cervix cancer and organ tumors.
Specification	USP27
Package	10, 50, 100, 200, 500 gms., packed in polythene pouch placed in stainless steel cans.